The Haemophilus influenzae Genome Database (HIGDB) is an unified database containing the genomic and proteomic information of the entire H. influenzae strains. The aim of this database is to manage a resource for the research community to execute varied searches against H. influenzae strains. The database has the inbuilt tools like BLAST, DNA motif search, the graphics based plugin, GBrowse and Jmol to visualize the genome and Protein Data Bank (PDB) structures of H. influenzae strains respectively. In addition, the database contributes the users to browse all annotations using either the simple or advanced Boolean based search tools. The database covers the significant points on general and cultutal characteristics, virulence factors, pathogenic mechanism and laboratory diagnosis of H. influenzae. A superior understanding of the genes responsible for virulence in these strains can aid researchers determine immunogen targets and drug candidates.