MDB - MELIOIDOSIS DATABASE

  Protein search results for - I2L6H5

Names and origin
Entry : I2L6H5 (unreviewed)
Entry name : I2L6H5_BURPE
Protein names : Kynureninase (EC 3.7.1.3) (L-kynurenine hydrolase)
Organism : Burkholderia pseudomallei 1258a
Organism ID : 1086032
Gene names : kynU
ORF names : BP1258A_2220
EC number : 3.7.1.3
History
Date of creation : 2012-07-11
Date of modification : 2014-07-09
Date of sequence modification : 2012-07-11
Protein attributes
Protein existence : Evidence at protein level
Gene Ontology (GO)
GO term name : 'de novo' NAD biosynthetic process from tryptophan; L-kynurenine catabolic process; anthranilate metabolic process; cytoplasm; kynureninase activity; pyridoxal phosphate binding; quinolinate biosynthetic process; tryptophan catabolic process
GO identifier : GO:0034354; GO:0097053; GO:0043420; GO:0005737; GO:0030429; GO:0030170; GO:0019805; GO:0006569
Keywords
Ligand & Biological process : Hydrolase; Pyridine nucleotide biosynthesis; Pyridoxal phosphate
General annotation
Pathway : Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1. Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3.
Sequence similarities : Belongs to Kynureninase family
Reference
PubMed ID : 22615773
Protein sequence
Length : 444 residues
>I2L6H5|I2L6H5_BURPE Burkholderia pseudomallei 1258a
MKTREEALALDRDDPLAPLREQFALPAGVIYLDGNSLGAQPRAAAARAQQVIGAEWGEGL
IRSWNTAGWFALPRRLGDRLAPLIGAADGEVAITDTISINLFKLLAAMLRHQARHAPKRR
VIVSERSNFPTDLYIAQGLIAQLDRDYELRLIDDPADLPDALDDETAVAMITHVNYRTGY
MHDMPSVTQTVRQAGALMLWDLAHSAGAVPVDLNGALADGAVGCTYKYLNGGPGSPAFVW
VPKRHQRAFEQPLSGWWGHRAPFAMQPAFEPDPGIARFLCGTQPIVSMSMVECGLDVFAQ
TDMHAIRRKSLALTDAFVALVESRCAGQPLKLVTPRAHHQRGSQASFEHPHGYEVMQALI
ARGVIGDYREPRILRFGFTPLYTRFVDVWDAVETLRDILDTEAWRAPEFATRAAVT