MDB - MELIOIDOSIS DATABASE

  Protein search results for - I2KNQ4

Names and origin
Entry : I2KNQ4 (unreviewed)
Entry name : I2KNQ4_BURPE
Protein names : 3-isopropylmalate dehydrogenase (EC 1.1.1.85) (3-IPM-DH) (Beta-IPM dehydrogenase)
Organism : Burkholderia pseudomallei 1258b
Organism ID : 1086033
Gene names : leuB
ORF names : BP1258B_4975
EC number : 1.1.1.85
History
Date of creation : 2012-07-11
Date of modification : 2014-07-09
Date of sequence modification : 2012-07-11
Protein attributes
Protein existence : Inferred from homology
Gene Ontology (GO)
GO term name : 3-isopropylmalate dehydrogenase activity; NAD binding; cytoplasm; leucine biosynthetic process; magnesium ion binding
GO identifier : GO:0003862; GO:0051287; GO:0005737; GO:0009098; GO:0000287
Keywords
Ligand & Biological process : Amino-acid biosynthesis; Branched-chain amino acid biosynthesis; Cytoplasm; Leucine biosynthesis; Magnesium; Manganese; Metal-binding; NAD; Oxidoreductase
General annotation
Pathway : Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 3/4.
Sequence similarities : Belongs to Isocitrate and isopropylmalate dehydrogenases family, LeuB type 1 subfamily
Subcellular location : Cytoplasm.
Reference
PubMed ID : 22615773
Protein sequence
Length : 379 residues
>I2KNQ4|I2KNQ4_BURPE Burkholderia pseudomallei 1258b
MKIAVLPGDGIGPEIVNEAVKVLNALDEKFELEQAPVGGAGYEASGHPLPDATLALAKEA
DAILFGAVGDWKYDSLERALRPEQAILGLRKHLELFANFRPAICYPQLVDASPLKPELVA
GLDILIVRELNGDIYFGQPRGVRAAPDGPFAGAREGFDTMRYSEPEVRRIAHVAFQAARK
RAKKLLSVDKSNVLETSQFWRDVMIDVSKEYADVELSHMYVDNAAMQLAKAPKQFDVIVT
GNMFGDILSDEASMLTGSIGMLPSASLDQRNKGLYEPSHGSAPDIAGKGIANPLATILSA
AMLLRYSLNRAEQADRIERAVKAVLEQGYRTGDIATPGCKQVGTAAMGDAVVAAL