EDB - Ebola Database

Protein search results for - Q5XX06

Names and origin
Entry : Q5XX06 (reviewed)
Entry name : VP40_EBOSU
Protein names : Matrix protein VP40 (Membrane-associated protein VP40)
Organism : Sudan ebolavirus (strain Uganda-00) (SEBOV) (Sudan Ebola virus)
Organism ID : 386033
Gene names : VP40
History
Date of creation : 2006-07-11
Date of modification : 2014-11-26
Date of sequence modification : 2004-11-23
Protein attributes
Protein existence : Evidence at protein level
Gene Ontology (GO)
GO term name : host cell plasma membrane; membrane; ribonucleoprotein complex; RNA binding; structural constituent of virion; viral budding via host ESCRT complex; viral release from host cell; virion
GO identifier : GO:0003723; GO:0020002; GO:0016020; GO:0030529; GO:0039660; GO:0039702; GO:0019076; GO:0019012
Keywords
Ligand & Biological process : 3D-structure; Complete proteome; Host cell membrane; Host membrane; Host-virus interaction; Membrane; RNA-binding; Ribonucleoprotein; Viral RNA replication; Viral budding; Viral budding via the host ESCRT complexes; Viral matrix protein; Virion; Virus exit from host cell
General annotation
Domains : Late-budding domains (L domains) are short sequence motifs essential for viral particle budding. They recruit proteins of the host ESCRT machinery (Endosomal Sorting Complex Required for Transport) or ESCRT-associated proteins. VP40 contains two overlapping L domains: a PTAP/PSAP motif, which interacts with the UEV domain of TSG101 and a PPXY motif which interacts with the WW domain 3 of NEDD4.
Sequence similarities : Belongs to Filoviridae matrix protein VP40 family
Subcellular location : Virion membrane {ECO:0000250}; Peripheral membrane
Reference
PubMed ID : 16139097
Protein sequence
Length : 350 residues
>Q5XX06|VP40_EBOSU Sudan ebolavirus (strain Uganda-00) (SEBOV) (Sudan Ebola virus)
MRRVTVPTAPPAYADIGYPMSMLPIKSSRAVSGIQQKQEVLPGMDTPSNSMRPVADDNID
HTSHTPNGVASAFILEATVNVISGPKVLMKQIPIWLPLGIADQKTYSFDSTTAAIMLASY
TITHFGKANNPLVRVNRLGQGIPDHPLRLLRMGNQAFLQEFVLPPVQLPQYFTFDLTALK
LVTQPLPAATWTDETPSNLSGALRPGLSFHPKLRPVLLPGKTGKKGHVSDLTAPDKIQTI
VNLMQDFKIVPIDPAKSIIGIEVPELLVHKLTGKKMSQKNGQPIIPVLLPKYIGLDPISP
GDLTMVITPDYDDCHSPASCSYLSEK